In the text below the tool there is more information on how the iron deficit is calculated. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Administer while the patient is in a reclined or semi-reclined position. Use Caution/Monitor. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Applies only to oral form of both agents. Am J Kid Dis 2001; 38 988991. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Recommended dosing and infusion rates for PI. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Properly discard this product when it is expired or no longer needed. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . Minor/Significance Unknown. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Accessed: 4/12/2011. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). gymnema decreases levels of iron sucrose by inhibition of GI absorption. Human studies not conducted. Either decreases levels of the other by inhibition of GI absorption. Modify Therapy/Monitor Closely. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Applies only to oral form of both agents. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Test Dose: Not required. Venofer is given as an infusion into a vein. an automated flowchart approach. ]Venofer treatment may be repeated if iron deficiency reoccurs. Individual plans may vary Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Use Caution/Monitor. The dosage of iron sucrose is expressed in mg of elemental iron. No additional iron to replenish stores. Applies only to oral form of both agents. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. 1000 mg. 20 MINUTES. Anemia caused by the depletion of iron is called iron deficiency anemia. Applies only to oral form of both agents. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Generic name: IRON SUCROSE 20mg in 1mL Sodium ferric gluconate (Ferrlecit) 62.5 mg . 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Slow or stop the infusion if adverse reactions occur. Applies only to oral form of both agents. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Information last revised December 2022. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Minor/Significance Unknown. Interaction only with oral iron administration. Oral and parenteral products - see background option for oral products. Applies only to oral form of both agents. 1995 Mar-Apr;11(2):163-8. This site complies with the HONcode standard for trust- worthy health information: verify here. Use Caution/Monitor. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. If we don't have the calculator you need we'll try to make it for you and add it to the website. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Use Caution/Monitor. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Ren Fail. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . The dosage of Venofer is expressed in mg of elemental iron. Avoid or Use Alternate Drug. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Official Journal of the International Society of Nephrology. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. World J Gastroenterol; 16(22): 27202725. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. commonly, these are "preferred" (on formulary) brand drugs. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Venofer [package insert]. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Minor/Significance Unknown. Venofer must only be administered intravenously either by slow injection or by infusion. Administer on 5 different occasions over a 14 day period. Applies only to oral form of both agents. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Total dose iron infusion: safety and efficacy in predialysis patients. Dosage form: injection, solution Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Minor (1)iron sucrose, benazepril. I. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. David McAuley, Pharm.D. Use Caution/Monitor. Use Caution/Monitor. J Med. Assessing new treatment options. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. provider for the most current information. Suggested regime: Prescribing instructions Prescribing a single/first dose: Applies only to oral form of both agents. Monitor Closely (1)trientine, iron sucrose. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Separate dosing of tetracyclines from these products. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. This site contains information for licensed healthcare professionals in the United States. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Observed Hb = the patients current hemoglobin in g/dl. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Applies only to oral form of both agents. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. The dosage of Venofer is expressed in mg of elemental iron. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. You will have to pay for your IV iron. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Am J Hosp Pharm. Anemia; 2015: 763576. Avoid or Use Alternate Drug. Applies only to oral form of both agents. If you log out, you will be required to enter your username and password the next time you visit. 1) Ganzoni AM. Applies only to oral form of both agents. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Schweiz Med Wochenschr. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Steps on how to print your input & results: 1. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. This drug is available at a higher level co-pay. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. iron sucrose decreases levels of manganese by inhibition of GI absorption. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Use Caution/Monitor. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. For liquid medications, also enter the value of the Medicine Concentration and choose . For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Applies only to oral form of both agents. US residents can call their local poison control center at 1-800-222-1222. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Either decreases levels of the other by inhibition of GI absorption. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in All Rights Reserved. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Use Caution/Monitor. Most Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Use Caution/Monitor. 1990 Feb;24(2):162-6. This site complies with the HONcode standard for trust- worthy health information: verify here. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Use alternatives if available. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. You can further save the PDF or print it. Minor/Significance Unknown. Ganzoni AM. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Fatal reactions have followed the test dose of iron dextran injection. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. (3) Known hypersensitivity to Venofer. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Use Caution/Monitor. Use Caution/Monitor. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright(c) 2023 First Databank, Inc. This cost includes the fee charged by the pharmacy. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Venofer has not been studied in patients younger than 2 years old. Applies only to oral form of both agents. Copyright 1993-2021 Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . ONE DOSE. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) https://www.uptodate.com/ (Requires subscription). The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. You may report side effects to Health Canada at 1-866-234-2345. Administer a test INFeD dose prior to the first therapeutic dose. Applies only to oral form of both agents. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Nutrition. Separate by at least 4 hours. . Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Learn how to store and discard medical supplies safely. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Applies only to oral form of both agents. Accessed: 4/12/2011. Med J Aust. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. 1970;100(7):301303. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Shirley, NY: American Regent, Inc.; 9/2020. Copyright 1993-2021 Most Applies only to oral form of both agents. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. 1. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Burns DL, Mascioli EA, Bistrian BR. The dosage of Venofer is expressed in mg of elemental iron. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. . Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Nutr Clin Pract. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. 2015: 763576. Venofer treatment may be repeated if necessary. Use Caution/Monitor. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) 2010;18(3). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Applies only to oral form of both agents. Medically reviewed by Drugs.com. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Applies only to oral form of both agents. For additional Safety Information, please see Full Prescribing Information. IDA diagnosis is based on full blood examination and on the serum ferritin level. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Manage and view all your plans together even plans in different states. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. You may need extra iron because of blood loss during kidney dialysis. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Applies only to oral form of both agents. The iron formulation choice remains for the clinician to make. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Minor (1)iron sucrose, captopril. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Use Caution/Monitor. Minor/Significance Unknown. Intravenous iron sucrose: establishing a safe dose. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. 2. 1970; 100(7):301-3. Ferritin and transferrin are also recommended monitoring . In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Applies only to oral form of both agents. Use Caution/Monitor. By using this form you agree with the storage and handling of your data by this website. Avoid or Use Alternate Drug. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. 1982;13(4):309-21. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. It can be expressed in mg per ml. The dosage of Venofer is expressed in mg of elemental iron. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. iron sucrose, benazepril.